Investigating maintenance of genome stability and DNA repair in humans
Publications
Recent papers:
Kupculak, M., Bai, F., Luo, Q., Yoshikawa, Y., Lopez-Martinez, D., Xu, H., Uphoff, S. and Cohn, M.A. (2023). Phosphorylation by ATR triggers FANCD2 chromatin loading and activates the Fanconi Anemia Pathway. Cell Rep. 42(7):112721. LinkPdf
Socha, A., Yang, D., Bulsiewicz, A., Yaprianto, K., Kupculak, M., Liang. C-C., Hadjicharalambous, A., Wu, R., Gygi, S.P. and Cohn, M.A. (2020). WRNIP1 is recruited to DNA interstrand crosslinks and promotes repair. Cell Rep. 32(1) LinkPdf
Lopez-Martinez, D., Kupculak, M., Yang, D., Yoshikawa, Y., Liang, C-C., Wu, R., Gygi, S.P. and Cohn, M.A. (2019). Phosphorylation of FANCD2 inhibits the FANCD2/FANCI complex and suppresses the Fanconi anemia pathway in the absence of DNA damage. Cell Rep. 27(10):2990-3005. LinkPdf
Liang, C-C., Li, Z., Lopez-Martinez, D., Nicholson, W.V., Vénien-Bryan, C. and Cohn, M.A. (2016). The FANCD2-FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2. Nat Commun. 7:12124. LinkPdf
Liang, C-C., Zhan, B., Yoshikawa, Y., Haas, W., Gygi, S.P. and Cohn, M.A. (2015). UHRF1 Is a Sensor for DNA Interstrand Crosslinks and Recruits FANCD2 to Initiate the Fanconi Anemia Pathway. Cell Rep. 10(12):1947-56. LinkPdf
Zhang, J., Dewar, J.M., Budzowska, M., Motnenko, A., Cohn, M.A. and Walter, J.C. (2015). DNA interstrand cross-link repair requires replication-fork convergence. Nat Struct Mol Biol. 22:242-7. LinkPdf